Self-Generated Movements with Unexpected Sensory Consequences
Babies learn about their limbs and how to use them from twitches they make during REM sleep, movements that are very different from those made while awake.
According to psychology graduate student Alexandre Tiriac, of University of Iowa, and first author of the study:
“Every time we move while awake, there is a mechanism in our brain that allows us to understand that it is we who made the movement.
But twitches seem to be different in that the brain is unaware that they are self-generated. And this difference between sleep and wake movements may be critical for how twitches, which are most frequent in early infancy, contribute to brain development.”
This latest discovery is further evidence that sleep twitches, whether in dogs, cats, or humans, are associated with brain development, and not dreams, says senior author Mark Blumberg, professor of psychology.
Not Chasing Rabbits
“Because twitches are so different from wake movements,” he says, “these data put another nail in the coffin of the ‘chasing rabbits’ interpretation of twitches.”
For the study, researchers looked at the brain activity of unanesthetized rats between 8 and 10 days of age. They measured the brain activity while the animals were awake and moving and again while the rats were in REM sleep and twitching.
What they discovered was puzzling, at first.
“We noticed there was a lot of brain activity during sleep movements but not when these animals were awake and moving,” Tiriac says.
The researchers proposed that sensations may be coming back from twitching limbs during REM sleep were being processed differently in the brain than awake movements because they lacked what is known as corollary discharge.
First introduced by researchers in 1950, corollary discharge is a split-second message sent to the brain that allows animals, including rats, crickets, humans and more, to recognize and filter out sensations generated from their own actions.
This filtering of sensations is what allows animals to distinguish between sensations arising from their own movements and those from stimuli in the outside world.
So, when researchers noticed an increase in brain activity while the newborn rats were twitching during REM sleep but not when the animals were awake and moving, they conducted several follow-up experiments to determine whether sleep twitching is a unique self-generated movement that is processed as if it lacks corollary discharge.
The experiments were consistent in supporting the idea that sensations arising from twitches are not filtered:
And without the filtering provided by corollary discharge, the sensations generated by twitching limbs are free to activate the brain and teach the newborn brain about the structure and function of the limbs.
“If twitches were like wake movements, the signals arising from twitching limbs would be filtered out,” Blumberg says. “That they are not filtered out suggests again that twitches are special—perhaps special because they are needed to activate developing brain circuits.”
The researchers were initially surprised to find the filtering system functioning so early in development, Blumberg says.
“But what surprised us even more was that corollary discharge appears to be suspended during sleep in association with twitching, a possibility that—to our knowledge—has never before been entertained.”