A recent scientific discovery may change the way scientists explore vaccine development and drug discovery for infectious diseases.
A team from Griffith University’s Institute for Glycomics, led by senior authors Professor Michael Jennings, Professor Victoria Korolik and Associate Professor Renato Morona (University of Adelaide), has shown an entirely new way that cells and macromolecules interact together.
Professor Jennings said the paper demonstrates that glycans, the complex sugar structures on cells linked to the spread of many diseases, can interact with each other at high affinity. Previous to this paper the interaction was not thought possible, or was considered a weak non-important interaction.
“We have discovered an entirely new way that cells and macromolecules interact with each other through interactions between bacterial glycan and human glycans,” he said.
“To develop new drugs and vaccines you have to understand these biological processes and before this we did not know they existed so this finding opens up the opportunity for a range of approaches we can use to block infections.”
Professor Jennings said the discovery was also a major contribution to fundamental science as well as the fight against infection disease and it would change the way the scientific community views these interactions in all living systems.
Cellular Level Glycan Interactions
The discovery was first made by Dr Christopher Day, whose observations couldn’t be explained any other way than with the hypothesis that glycans can interact with other glycans at the cellular level.
The team, which also included Michael Apicella from University of Iowa, then set out to show over 60 high-affinity interactions in four different types of bacteria pathogens.
These included Campylobacter jejuni, Salmonella typhimurium and Shigella flexneri, which are all food borne bacteria as well as in Haemophilus influenzae, which causes illnesses such as pneumonia, chronic obstructive pulmonary disease and middle ear infections.
Professor Jennings said this discovery was important in understanding how bacteria cause disease in humans and developing drugs and vaccines to block these interactions.
Christopher J. Day, et al.
Glycan:glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells
PNAS December 16, 2015 doi: 10.1073/pnas.1421082112
Photo: Institute for Glycomics researchers Professor Michael Jennings and Dr Christopher Day. Credit: Griffith University