Biomedical engineers have developed specialized white blood cells— dubbed “super natural killer cells”— that seek out cancer cells in lymph nodes with only one purpose: destroy them to halt the onset of metastasis.
Says Michael R. King, professor of biomedical engineering at Cornell University and senior author of the paper published in the journal Biomaterials:
“We want to see lymph node metastasis become a thing of the past.”
For tumor cells, the lymph nodes are a staging area and play a key role in advancing metastasis throughout the body.
Researchers were able to kill cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis-Inducing Ligand) that attach to “natural killer” cells (a type of white blood cell) residing in the lymph nodes.
Self-destructing Cancer Cells
These natural killer cells became the “super natural killer cells” that find the cancerous cells and induce apoptosis, where the cancer cells self-destruct and disintegrate, preventing the lymphatic spread of cancer any further, King says.
“In our research, we use nanoparticles— the liposomes we have created with TRAIL protein— and attach them to natural killer cells, to create what we call ‘super natural killer cells’ and then these completely eliminate lymph node metastases in mice.”
In cancer progression, there are four stages. At stage I, the tumor is small and has yet to progress to the lymph nodes. In stages II and III, the tumors have grown and likely will have spread to the lymph nodes.
At the stage IV, the cancer has advanced from the lymph nodes to organs and other parts of the body.
Lymph Node Metastases
Between 29 and 37 percent of patients with breast, colorectal, and lung cancers are diagnosed with metastases in their tumor-draining lymph nodes–those lymph nodes that lie downstream from the tumor, and those patients are at a higher risk for distant-organ metastases and later-stage cancer diagnoses.
Research published in January 2014 demonstrated that by attaching the TRAIL protein to white blood cells, metastasizing cancer cells in the bloodstream were annihilated.
“So, now we have technology to eliminate bloodstream metastasis—our previous work—and also lymph node metastases,” King says.
Siddarth Chandrasekaran, Maxine F. Chan, Jiahe Li, Michael R. King
Super natural killer cells that target metastases in the tumor draining lymph nodes
Biomaterials Volume 77, January 2016, Pages 66–76
Photo: Eran Sandler/Flickr