Prefrontal Dorsolateral Cortex Suppresses Acts Of Revenge

The more active the prefrontal dorsolateral cortex (DLPFC) is during the provocation phase of anger, the less the participant takes revenge, research from the University of Geneva has shown. The findings shed new light on which brain areas underlie the feelings of anger and the regulation of related punishment behaviors.

The University of Geneva (UNIGE) team developed an economic game in which a participant is confronted with the fair behaviour of one player and the unfair provocations of another player. They then observed, through brain imaging, which areas were activated as the study participant experienced unfairness and anger. In a second phase, scientists gave the participant the opportunity to take revenge.

Until now, research on anger and the vengeful behaviour that results from it has been based primarily on the recall of a feeling of anger by the participants, or on the interpretation of anger on photographed faces. Olga Klimecki-Lenz, a researcher at UNIGE’s Swiss Center for Affective Science (CISA), wanted to locate which areas of the brain reacted when the person became angry and how this feeling materialized into vengeful behaviour.

The Inequality Game

25 people took part in the Inequality Game, an economic game created by Olga Klimecki-Lenz to trigger a feeling of injustice, then anger, before offering the “victim” the possibility of revenge.

“The participant has economic interactions with two players, whose behaviour is actually pre-programmed – which he doesn’t know about. One is friendly, offers the participant only mutually beneficial financial interactions and sends nice messages, while the other player makes sure to multiply only his own profits, going against the participant’s interest and sending annoying messages,”

explained Olga Klimecki-Lenz.

The three phases of the Inequality Game

Study design.
(a) The three phases of the Inequality Game (given in successive scanning runs).
(b) Depiction of event frames of a single trial in the high power phase with their respective duration.
Credit: Klimecki, et al. CC-BY.

The game takes place in three phases, during which the participant is installed in a magnetic resonance imaging (MRI) scanner allowing scientists to measure his brain activity. The participant is then confronted with the photographs of the other two players and the messages and financial transactions that he receives and issues. In the first phase, the participant is in control and chooses which profits he distributes to whom.

“We noticed that on average, participants here are fair towards both other players,”

said Klimecki-Lenz. The second phase is that of provocation: the participant passively receives the decisions of the other two players, and especially the provocations and injustice of the unfair player, which induce a feeling of anger rated on a scale from 0 to 10 by the participant himself.

In the last phase, the participant is again the master of the game and can choose to take revenge or not by penalizing the other two players. Overall, participants remained nice to the fair player, but took revenge for the injustices committed by the unfair player.

Amygdala Activations

The provocation phase played a crucial role in localizing the feeling of anger in the brain.

“It was during this phase that we were able to identify which areas were related to feelings of anger,”

added Olga Klimecki-Lenz.

Thanks to MRI, researchers observed activity of the superior temporal lobe, but also of the amygdala, known mainly for its role in the feeling of fear and in processing the relevance of emotions, when participants looked at the photograph of the unfair player. These two areas correlated with feelings of anger: the higher the level of anger reported by the participant, the stronger their activity.

Defused Revenge

Olga Klimecki-Lenz explained,

“But the Inequality game allowed us above all to identify the crucial role of the prefrontal dorsolateral cortex (DLPFC), a zone which is key for the regulation of emotions and which is located at the front of the brain!”

On average, participants took revenge on the unfair player. However, the researchers observed a variability in behaviour that shows that 11 participants nevertheless remained fair to the unfair player.

But why so?

The CISA team observed that the greater the DLPFC activity during the provocation phase, the less participants punished the unfair player. On the contrary, low DLPFC activity was associated with a more pronounced revenge on the participant following provocation by the unfair player.

“We observed that DLPFC is coordinated with the motor cortex that directs the hand that makes the choice of vengeful behavior or not. There is therefore a direct correlation between brain activity in DLPFC, known for emotional regulation, and behavioural choices,”

continued the CISA researcher.

The work was supported by a Marie Curie fellowship from the European Union Seventh Framework Programme and by the National Center of Competence in Research (NCCR) for the Affective Sciences, financed by a grant from the Swiss National Science Foundation.

Olga M. Klimecki, David Sander & Patrik Vuilleumier
Distinct Brain Areas involved in Anger versus Punishment during Social Interactions
Scientific Reports volume 8, Article number: 10556 (2018)

Top Image: Klimecki, et al. CC-BY.